La téléphonie mobile peut doubler le risque de cancer de la thyroïde Imprimer
Écrit par Eric   
Lundi, 11 Mai 2020 22:59

(13/5/20) Une nouvelle étude scientifique menée à New Haven dans le Connecticut et publiée en mars 2020 dans Elsevier Environmental Research, montre que des personnes prédisposées génétiquement au cancer de la thyroïde augmentent leur risque en utilisant la téléphonie mobile. https://www.sciencedirect.com/science/article/abs/pii/S0013935119308102

 

Highlights
 
The interaction between cell phone use and genetic variants on thyroid cancer was investigated in this study.
When some genetic variants were present, cell phone use was significantly associated with thyroid cancer.
The association increased when cell phone use duration and frequency increased.
Genetic susceptibility may modify the association between cell phone use and thyroid cancer.
 
Abstract
 
Emerging studies have provided evidence on the carcinogenicity of radiofrequency radiation (RFR) from cell phones. This study aims to test the genetic susceptibility on the association between cell phone use and thyroid cancer. Population-based case-control study was conducted in Connecticut between 2010 and 2011 including 440 thyroid cancer cases and 465 population-based controls with genotyping information for 823 single nucleotide polymorphisms (SNPs) in 176 DNA genes. We used multivariate unconditional logistic regression models to estimate the genotype-environment interaction between each SNP and cell phone use and to estimate the association with cell phone use in populations according to SNP variants. Ten SNPs had P < 0.01 for interaction in all thyroid cancers. In the common homozygote groups, no association with cell phone use was observed. In the variant group (heterozygotes and rare homozygotes), cell phone use was associated with an increased risk for rs11070256 (odds ratio (OR): 2.36, 95% confidence interval (CI): 1.30–4.30), rs1695147 (OR: 2.52, 95% CI: 1.30–4.90), rs6732673 (OR: 1.59, 95% CI: 1.01–2.49), rs396746 (OR: 2.53, 95% CI: 1.13–5.65), rs12204529 (OR: 2.62, 95% CI: 1.33–5.17), and rs3800537 (OR: 2.64, 95% CI: 1.30–5.36) with thyroid cancers. In small tumors, increased risk was observed for 5 SNPs (rs1063639, rs1695147, rs11070256, rs12204529 and rs3800537), In large tumors, increased risk was observed for 3 SNPs (rs11070256, rs1695147, and rs396746). Our result suggests that genetic susceptibilities modify the associations between cell phone use and risk of thyroid cancer. The findings provide more evidence for RFR carcinogenic group classification.
Jiajun Luo Hang Li Nicole C.Deziel Huang Huang Nan Zhao Shuangge Ma Xin Ni RobertUdelsman Yawei Zhang
Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA
Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA
Peking Union Medical College Hospital, Beijing, China
Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA
Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University & Capital Medical University, Beijing, China
Big Data and Engineering Research Center, Beijing Children's Hospital, Capital Medical University, Beijing, China
Endocrine Neoplasm Institute, Miami Cancer Institute, Miami, FL, USA
Section of Surgical Outcomes and Epidemiology, Department of Surgery, Yale School of Medicine, New Haven, CT, USA
Received 22 October 2019, Revised 4 December 2019, Accepted 5 December 2019, Available online 6 December 2019.

 

https://www.sciencedirect.com/science/article/abs/pii/S0013935119308102

 

 
Mise à jour le Lundi, 11 Mai 2020 23:08